| 9/9/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | H | NO | 6-24 | L | 4 | 177 | 44.3 | 51 | 0 |
| 9/23/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | A | IND | 26-42 | L | 4 | 189 | 47.3 | 57 | 0 |
| 9/30/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | H | PIT | 3-20 | L | 6 | 304 | 50.7 | 57 | 0 |
| 10/7/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | H | NYJ | 36-42 | L | 3 | 147 | 49.0 | 56 | 0 |
| 10/18/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | A | JAC | 13-10 | W | 4 | 148 | 37.0 | 64 | 0 |
| 10/28/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | A | SD | 24-27 | L | 4 | 164 | 41.0 | 44 | 0 |
| 11/4/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | H | IND | 14-30 | L | 6 | 262 | 43.7 | 53 | 0 |
| 11/11/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | A | NE | 11-21 | L | 5 | 136 | 27.2 | 39 | 0 |
| 11/18/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | H | SEA | 20-23 | L | 3 | 117 | 39.0 | 43 | 0 |
| 11/25/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | H | MIA | 27-34 | L | 6 | 232 | 38.7 | 48 | 0 |
| 12/2/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | A | SF | 0-35 | L | 4 | 189 | 47.3 | 66 | 0 |
| 12/9/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | H | CAR | 25-24 | W | 6 | 233 | 38.8 | 52 | 0 |
| 12/16/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | H | NE | 9-12 | L | 8 | 328 | 41.0 | 58 | 0 |
| 12/23/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | A | ATL | 30-33 | L | 5 | 210 | 42.0 | 53 | 0 |
| 12/30/2001 | 2001 Buffalo Bills (NFL)2001 BUF NFL | A | NYJ | 14-9 | W | 6 | 179 | 29.8 | 47 | 0 |
| 1/6/2002 | 2001 Buffalo Bills (NFL)2001 BUF NFL | A | MIA | 7-34 | L | 6 | 247 | 41.2 | 50 | 0 |
| 9/8/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | H | NYJ | 31-37 | L | 1 | 64 | 64.0 | 64 | 1 |
| 9/15/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | A | MIN | 45-39 | W | 5 | 203 | 40.6 | 61 | 0 |
| 9/22/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | A | DEN | 23-28 | L | 7 | 340 | 48.6 | 70 | 0 |
| 9/29/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | H | CHIB | 33-27 | W | 3 | 153 | 51.0 | 67 | 0 |
| 10/6/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | H | OAK | 31-49 | L | 5 | 243 | 48.6 | 56 | 0 |
| 10/13/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | A | HOU | 31-24 | W | 4 | 180 | 45.0 | 61 | 0 |
| 10/20/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | A | MIA | 23-10 | W | 6 | 305 | 50.8 | 62 | 0 |
| 10/27/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | H | DET | 24-17 | W | 6 | 220 | 36.7 | 48 | 0 |
| 11/3/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | H | NE | 7-38 | L | 3 | 93 | 31.0 | 40 | 0 |
| 11/17/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | A | KC | 16-17 | L | 3 | 126 | 42.0 | 46 | 0 |
| 11/24/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | A | NYJ | 13-31 | L | 1 | 44 | 44.0 | 44 | 0 |
| 12/1/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | H | MIA | 38-21 | W | 3 | 90 | 30.0 | 36 | 0 |
| 12/8/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | A | NE | 17-27 | L | 3 | 130 | 43.3 | 57 | 0 |
| 12/15/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | H | SD | 20-13 | W | 8 | 293 | 36.6 | 58 | 0 |
| 12/22/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | A | GB | 0-10 | L | 6 | 283 | 47.2 | 84 | 0 |
| 12/29/2002 | 2002 Buffalo Bills (NFL)2002 BUF NFL | H | CIN | 27-9 | W | 2 | 77 | 38.5 | 44 | 0 |
| 9/7/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | H | NE | 31-0 | W | 4 | 226 | 56.5 | 71 | 0 |
| 9/14/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | A | JAC | 38-17 | W | 2 | 97 | 48.5 | 56 | 0 |
| 9/21/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | A | MIA | 7-17 | L | 7 | 350 | 50.0 | 64 | 0 |
| 9/28/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | H | PHI | 13-23 | L | 4 | 164 | 41.0 | 46 | 0 |
| 10/5/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | H | CIN | 22-16 | W | 7 | 302 | 43.1 | 60 | 0 |
| 10/12/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | A | NYJ | 3-30 | L | 4 | 190 | 47.5 | 56 | 0 |
| 10/19/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | H | WAS | 24-7 | W | 6 | 291 | 48.5 | 59 | 0 |
| 10/26/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | A | KC | 5-38 | L | 3 | 126 | 42.0 | 53 | 0 |
| 11/9/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | A | DAL | 6-10 | L | 9 | 364 | 40.4 | 54 | 0 |
| 11/16/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | H | HOU | 10-12 | L | 6 | 234 | 39.0 | 48 | 0 |
| 11/23/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | H | IND | 14-17 | L | 6 | 294 | 49.0 | 64 | 0 |
| 11/30/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | A | NYG | 24-7 | W | 6 | 251 | 41.8 | 50 | 0 |
| 12/7/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | H | NYJ | 17-6 | W | 4 | 161 | 40.3 | 54 | 0 |
| 12/14/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | A | TEN | 26-28 | L | 7 | 307 | 43.9 | 56 | 0 |
| 12/21/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | H | MIA | 3-20 | L | 6 | 263 | 43.8 | 59 | 0 |
| 12/27/2003 | 2003 Buffalo Bills (NFL)2003 BUF NFL | A | NE | 0-31 | L | 4 | 168 | 42.0 | 52 | 0 |
| 9/12/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | H | JAC | 10-13 | L | 5 | 223 | 44.6 | 80 | 0 |
| 9/19/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | A | OAK | 10-13 | L | 5 | 199 | 39.8 | 63 | 0 |
| 10/3/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | H | NE | 17-31 | L | 5 | 256 | 51.2 | 63 | 0 |
| 10/10/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | A | NYJ | 14-16 | L | 7 | 256 | 36.6 | 46 | 0 |
| 10/17/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | H | MIA | 20-13 | W | 3 | 159 | 53.0 | 59 | 0 |
| 10/24/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | A | BAL | 6-20 | L | 4 | 154 | 38.5 | 52 | 0 |
| 10/31/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | H | ARI | 38-14 | W | 7 | 309 | 44.1 | 68 | 0 |
| 11/7/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | H | NYJ | 22-17 | W | 7 | 292 | 41.7 | 64 | 0 |
| 11/14/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | A | NE | 6-29 | L | 5 | 240 | 48.0 | 58 | 0 |
| 11/21/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | H | STL | 37-17 | W | 4 | 165 | 41.3 | 51 | 0 |
| 11/28/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | A | SEA | 38-9 | W | 1 | 36 | 36.0 | 36 | 0 |
| 12/5/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | A | MIA | 42-32 | W | 9 | 393 | 43.7 | 63 | 0 |
| 12/12/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | H | CLE | 37-7 | W | 3 | 114 | 38.0 | 53 | 0 |
| 12/19/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | A | CIN | 33-17 | W | 5 | 225 | 45.0 | 60 | 0 |
| 12/26/2004 | 2004 Buffalo Bills (NFL)2004 BUF NFL | A | SF | 41-7 | W | 1 | 36 | 36.0 | 36 | 0 |
| 1/2/2005 | 2004 Buffalo Bills (NFL)2004 BUF NFL | H | PIT | 24-29 | L | 6 | 268 | 44.7 | 62 | 0 |
| 9/11/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | H | HOU | 22-7 | W | 5 | 203 | 40.6 | 58 | 0 |
| 9/18/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | A | TB | 3-19 | L | 7 | 305 | 43.6 | 60 | 0 |
| 9/25/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | H | ATL | 16-24 | L | 3 | 141 | 47.0 | 60 | 0 |
| 10/2/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | A | NO | 7-19 | L | 5 | 267 | 53.4 | 59 | 0 |
| 10/9/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | H | MIA | 20-14 | W | 6 | 301 | 50.2 | 63 | 0 |
| 10/16/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | H | NYJ | 27-17 | W | 4 | 171 | 42.8 | 49 | 0 |
| 10/23/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | A | OAK | 17-38 | L | 4 | 180 | 45.0 | 53 | 0 |
| 10/30/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | A | NE | 16-21 | L | 2 | 77 | 38.5 | 49 | 0 |
| 11/13/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | H | KC | 14-3 | W | 5 | 241 | 48.2 | 53 | 0 |
| 11/20/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | A | SD | 10-48 | L | 4 | 194 | 48.5 | 60 | 0 |
| 11/27/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | H | CAR | 9-13 | L | 4 | 193 | 48.3 | 55 | 0 |
| 12/4/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | A | MIA | 23-24 | L | 8 | 353 | 44.1 | 53 | 0 |
| 12/11/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | H | NE | 7-35 | L | 6 | 262 | 43.7 | 68 | 0 |
| 12/17/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | H | DEN | 17-28 | L | 6 | 254 | 42.3 | 52 | 0 |
| 12/24/2005 | 2005 Buffalo Bills (NFL)2005 BUF NFL | A | CIN | 37-27 | W | 1 | 52 | 52.0 | 52 | 0 |
| 1/1/2006 | 2005 Buffalo Bills (NFL)2005 BUF NFL | A | NYJ | 26-30 | L | 1 | 48 | 48.0 | 48 | 0 |
| 9/10/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | A | NE | 17-19 | L | 5 | 201 | 40.2 | 54 | 0 |
| 9/17/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | A | MIA | 16-6 | W | 6 | 248 | 41.3 | 52 | 0 |
| 9/24/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | H | NYJ | 20-28 | L | 2 | 99 | 49.5 | 58 | 0 |
| 10/1/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | H | MIN | 17-12 | W | 7 | 264 | 37.7 | 65 | 0 |
| 10/8/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | A | CHIB | 7-40 | L | 6 | 347 | 57.8 | 66 | 0 |
| 10/15/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | A | DET | 17-20 | L | 7 | 289 | 41.3 | 50 | 0 |
| 10/22/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | H | NE | 6-28 | L | 5 | 221 | 44.2 | 53 | 0 |
| 11/5/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | H | GB | 24-10 | W | 8 | 379 | 47.4 | 65 | 0 |
| 11/12/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | A | IND | 16-17 | L | 4 | 197 | 49.3 | 61 | 0 |
| 11/19/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | A | HOU | 24-21 | W | 7 | 328 | 46.9 | 62 | 0 |
| 11/26/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | H | JAC | 27-24 | W | 6 | 265 | 44.2 | 56 | 0 |
| 12/3/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | H | SD | 21-24 | L | 7 | 279 | 39.9 | 60 | 0 |
| 12/10/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | A | NYJ | 31-13 | W | 6 | 243 | 40.5 | 56 | 0 |
| 12/17/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | H | MIA | 21-0 | W | 7 | 271 | 38.7 | 51 | 0 |
| 12/24/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | H | TEN | 29-30 | L | 2 | 80 | 40.0 | 47 | 0 |
| 12/31/2006 | 2006 Buffalo Bills (NFL)2006 BUF NFL | A | BAL | 7-19 | L | 7 | 301 | 43.0 | 55 | 0 |
| 9/9/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | H | DEN | 14-15 | L | 6 | 262 | 43.7 | 50 | 0 |
| 9/16/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | A | PIT | 3-26 | L | 4 | 175 | 43.8 | 46 | 0 |
| 9/23/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | A | NE | 7-38 | L | 7 | 343 | 49.0 | 75 | 0 |
| 9/30/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | H | NYJ | 17-14 | W | 3 | 116 | 38.7 | 49 | 0 |
| 10/8/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | H | DAL | 24-25 | L | 5 | 237 | 47.4 | 59 | 0 |
| 10/21/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | H | BAL | 19-14 | W | 5 | 229 | 45.8 | 53 | 0 |
| 10/28/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | A | NYJ | 13-3 | W | 6 | 206 | 34.3 | 43 | 0 |
| 11/4/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | H | CIN | 33-21 | W | 2 | 66 | 33.0 | 37 | 0 |
| 11/11/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | A | MIA | 13-10 | W | 6 | 278 | 46.3 | 60 | 0 |
| 11/18/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | H | NE | 10-56 | L | 4 | 146 | 36.5 | 43 | 0 |
| 11/25/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | A | JAC | 14-36 | L | 4 | 151 | 37.8 | 43 | 0 |
| 12/2/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | A | WAS | 17-16 | W | 4 | 140 | 35.0 | 42 | 0 |
| 12/9/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | H | MIA | 38-17 | W | 6 | 223 | 37.2 | 45 | 0 |
| 12/16/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | A | CLE | 0-8 | L | 7 | 251 | 35.9 | 50 | 0 |
| 12/23/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | H | NYG | 21-38 | L | 7 | 267 | 38.1 | 52 | 0 |
| 12/30/2007 | 2007 Buffalo Bills (NFL)2007 BUF NFL | A | PHI | 9-17 | L | 5 | 212 | 42.4 | 56 | 0 |
| 9/7/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | H | SEA | 34-10 | W | 9 | 419 | 46.6 | 59 | 0 |
| 9/14/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | A | JAC | 20-16 | W | 3 | 143 | 47.7 | 51 | 0 |
| 9/21/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | H | OAK | 24-23 | W | 5 | 238 | 47.6 | 62 | 0 |
| 9/28/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | A | STL | 31-14 | W | 6 | 269 | 44.8 | 62 | 0 |
| 10/5/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | A | ARI | 17-41 | L | 2 | 93 | 46.5 | 55 | 0 |
| 10/19/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | H | SD | 23-14 | W | 2 | 105 | 52.5 | 56 | 0 |
| 10/26/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | A | MIA | 16-25 | L | 3 | 142 | 47.3 | 59 | 0 |
| 11/2/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | H | NYJ | 17-26 | L | 1 | 39 | 39.0 | 39 | 0 |
| 11/9/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | A | NE | 10-20 | L | 5 | 208 | 41.6 | 60 | 0 |
| 11/17/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | H | CLE | 27-29 | L | 3 | 108 | 36.0 | 40 | 0 |
| 11/23/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | A | KC | 54-31 | W | 2 | 83 | 41.5 | 48 | 0 |
| 11/30/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | H | SF | 3-10 | L | 3 | 78 | 26.0 | 29 | 0 |
| 12/7/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | H | MIA | 3-16 | L | 5 | 215 | 43.0 | 52 | 0 |
| 12/14/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | A | NYJ | 27-31 | L | 3 | 166 | 55.3 | 63 | 0 |
| 12/21/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | A | DEN | 30-23 | W | 3 | 158 | 52.7 | 57 | 0 |
| 12/28/2008 | 2008 Buffalo Bills (NFL)2008 BUF NFL | H | NE | 0-13 | L | 3 | 93 | 31.0 | 45 | 0 |
| 9/14/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | A | NE | 24-25 | L | 4 | 171 | 42.8 | 55 | 0 |
| 9/20/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | H | TB | 33-20 | W | 3 | 142 | 47.3 | 57 | 0 |
| 9/27/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | H | NO | 7-27 | L | 9 | 419 | 46.6 | 58 | 0 |
| 10/4/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | A | MIA | 10-38 | L | 5 | 257 | 51.4 | 61 | 0 |
| 10/11/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | H | CLE | 3-6 | L | 7 | 364 | 52.0 | 66 | 0 |
| 10/18/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | A | NYJ | 16-13 | W | 8 | 334 | 41.8 | 51 | 0 |
| 10/25/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | A | CAR | 20-9 | W | 8 | 360 | 45.0 | 55 | 0 |
| 11/1/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | H | HOU | 10-31 | L | 6 | 288 | 48.0 | 61 | 0 |
| 11/15/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | A | TEN | 17-41 | L | 5 | 210 | 42.0 | 53 | 0 |
| 11/22/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | A | JAC | 15-18 | L | 4 | 202 | 50.5 | 58 | 0 |
| 11/29/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | H | MIA | 31-14 | W | 3 | 153 | 51.0 | 66 | 0 |
| 12/3/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | H | NYJ | 13-19 | L | 7 | 336 | 48.0 | 61 | 0 |
| 12/13/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | A | KC | 16-10 | W | 4 | 212 | 53.0 | 73 | 0 |
| 12/20/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | H | NE | 10-17 | L | 5 | 190 | 38.0 | 43 | 0 |
| 12/27/2009 | 2009 Buffalo Bills (NFL)2009 BUF NFL | A | ATL | 3-31 | L | 7 | 350 | 50.0 | 60 | 0 |
| 1/3/2010 | 2009 Buffalo Bills (NFL)2009 BUF NFL | H | IND | 30-7 | W | 5 | 204 | 40.8 | 47 | 0 |
| 9/12/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | H | MIA | 10-15 | L | 7 | 298 | 42.6 | 53 | 0 |
| 9/19/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | A | GB | 7-34 | L | 5 | 232 | 46.4 | 51 | 0 |
| 9/26/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | A | NE | 30-38 | L | 1 | 33 | 33.0 | 33 | 0 |
| 10/3/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | H | NYJ | 14-38 | L | 9 | 395 | 43.9 | 55 | 0 |
| 10/10/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | H | JAC | 26-36 | L | 4 | 194 | 48.5 | 61 | 0 |
| 10/24/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | A | BAL | 34-37 | L | 2 | 90 | 45.0 | 53 | 0 |
| 10/31/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | A | KC | 10-13 | L | 7 | 309 | 44.1 | 56 | 0 |
| 11/7/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | H | CHIB | 19-22 | L | 3 | 87 | 29.0 | 38 | 0 |
| 11/14/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | H | DET | 14-12 | W | 7 | 297 | 42.4 | 51 | 0 |
| 11/21/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | A | CIN | 49-31 | W | 1 | 44 | 44.0 | 44 | 0 |
| 11/28/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | H | PIT | 16-19 | L | 5 | 182 | 36.4 | 47 | 0 |
| 12/5/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | A | MIN | 14-38 | L | 6 | 265 | 44.2 | 55 | 0 |
| 12/12/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | H | CLE | 13-6 | W | 4 | 174 | 43.5 | 52 | 0 |
| 12/19/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | A | MIA | 17-14 | W | 6 | 217 | 36.2 | 60 | 0 |
| 12/26/2010 | 2010 Buffalo Bills (NFL)2010 BUF NFL | H | NE | 3-34 | L | 2 | 68 | 34.0 | 36 | 0 |
| 1/2/2011 | 2010 Buffalo Bills (NFL)2010 BUF NFL | A | NYJ | 7-38 | L | 6 | 296 | 49.3 | 59 | 0 |
| 9/11/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | A | KC | 41-7 | W | 5 | 257 | 51.4 | 63 | 0 |
| 9/18/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | H | OAK | 38-35 | W | 2 | 99 | 49.5 | 58 | 0 |
| 9/25/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | H | NE | 34-31 | W | 5 | 253 | 50.6 | 63 | 0 |
| 10/2/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | A | CIN | 20-23 | L | 8 | 413 | 51.6 | 65 | 0 |
| 10/9/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | H | PHI | 31-24 | W | 5 | 251 | 50.2 | 64 | 0 |
| 10/16/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | A | NYG | 24-27 | L | 3 | 136 | 45.3 | 64 | 0 |
| 10/30/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | H | WAS | 23-0 | W | 3 | 135 | 45.0 | 52 | 0 |
| 11/6/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | H | NYJ | 11-27 | L | 4 | 190 | 47.5 | 66 | 0 |
| 11/13/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | A | DAL | 7-44 | L | 3 | 156 | 52.0 | 59 | 0 |
| 11/20/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | A | MIA | 8-35 | L | 6 | 295 | 49.2 | 56 | 1 |
| 11/27/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | A | NYJ | 24-28 | L | 7 | 313 | 44.7 | 54 | 0 |
| 12/4/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | H | TEN | 17-23 | L | 4 | 194 | 48.5 | 62 | 0 |
| 12/11/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | A | SD | 10-37 | L | 2 | 71 | 35.5 | 55 | 0 |
| 12/18/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | H | MIA | 23-30 | L | 8 | 384 | 48.0 | 62 | 0 |
| 12/24/2011 | 2011 Buffalo Bills (NFL)2011 BUF NFL | H | DEN | 40-14 | W | 4 | 201 | 50.3 | 58 | 0 |
| 1/1/2012 | 2011 Buffalo Bills (NFL)2011 BUF NFL | A | NE | 21-49 | L | 3 | 124 | 41.3 | 61 | 0 |
| 9/9/2012 | 2012 Buffalo Bills (NFL)2012 BUF NFL | A | NYJ | 28-48 | L | 2 | 81 | 40.5 | 44 | 0 |
| 9/16/2012 | 2012 Buffalo Bills (NFL)2012 BUF NFL | H | KC | 35-17 | W | 7 | 349 | 49.9 | 60 | 0 |
| 9/23/2012 | 2012 Buffalo Bills (NFL)2012 BUF NFL | A | CLE | 24-14 | W | 6 | 252 | 42.0 | 66 | 0 |
| 10/1/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | H | CHIB | 18-34 | L | 3 | 111 | 37.0 | 41 | 0 |
| 10/21/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | A | CAR | 19-14 | W | 4 | 197 | 49.3 | 59 | 0 |
| 10/28/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | H | NYG | 24-29 | L | 4 | 165 | 41.3 | 50 | 0 |
| 11/4/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | A | ATL | 13-19 | L | 4 | 182 | 45.5 | 53 | 0 |
| 11/11/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | A | PHI | 38-23 | W | 7 | 288 | 41.1 | 53 | 0 |
| 11/18/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | H | CLE | 23-20 | W | 7 | 302 | 43.1 | 53 | 0 |
| 11/22/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | H | WAS | 31-38 | L | 3 | 170 | 56.7 | 64 | 0 |
| 12/2/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | H | PHI | 38-33 | W | 3 | 156 | 52.0 | 63 | 0 |
| 12/9/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | A | CIN | 20-19 | W | 5 | 165 | 33.0 | 49 | 0 |
| 12/16/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | H | PIT | 27-24 | W | 6 | 288 | 48.0 | 60 | 0 |
| 12/23/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | H | NO | 31-34 | L | 6 | 307 | 51.2 | 63 | 0 |
| 12/30/2012 | 2012 Dallas Cowboys (NFL)2012 DAL NFL | A | WAS | 18-28 | L | 4 | 166 | 41.5 | 50 | 0 |
| 10/13/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | H | CIN | 24-27 | L | 5 | 244 | 48.8 | 57 | 0 |
| 10/20/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | A | MIA | 23-21 | W | 7 | 318 | 45.4 | 62 | 0 |
| 10/27/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | A | NO | 17-35 | L | 3 | 137 | 45.7 | 53 | 0 |
| 11/3/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | H | KC | 13-23 | L | 3 | 108 | 36.0 | 47 | 0 |
| 11/10/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | A | PIT | 10-23 | L | 9 | 332 | 36.9 | 56 | 0 |
| 11/17/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | H | NYJ | 37-14 | W | 6 | 200 | 33.3 | 57 | 0 |
| 12/1/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | H | ATL | 31-34 | L | 7 | 299 | 42.7 | 51 | 0 |
| 12/8/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | A | TB | 6-27 | L | 7 | 306 | 43.7 | 55 | 0 |
| 12/15/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | A | JAC | 27-20 | W | 4 | 180 | 45.0 | 53 | 0 |
| 12/22/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | H | MIA | 19-0 | W | 6 | 218 | 36.3 | 52 | 0 |
| 12/29/2013 | 2013 Buffalo Bills (NFL)2013 BUF NFL | A | NE | 20-34 | L | 4 | 169 | 42.3 | 51 | 0 |
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| Last Updated: March 29, 2026 |