| SCORES |
|---|
| Day | Date | | Opponent | Result | Location | Venue | Attendance |
|---|
| Sat | 8/15/2026 | H | Carolina Panthers | | | | | Orchard Park, NY | Highmark Stadium | |
| Sat | 8/22/2026 | A | Cleveland Browns | | | | | Cleveland, OH | Huntingon Bank Field | |
| Thu | 8/27/2026 | H | Pittsburgh Steelers | | | | | Orchard Park, NY | Highmark Stadium | |
| Sun | 9/13/2026 | A | Houston Texans | | | | | Houston, TX | NRG Stadium | |
| Thu | 9/17/2026 | H | Detroit Lions | | | | | Orchard Park, NY | Highmark Stadium | |
| Sun | 9/27/2026 | H | Los Angeles Chargers | | | | | Orchard Park, NY | Highmark Stadium | |
| Sun | 10/4/2026 | H | New England Patriots | | | | | Orchard Park, NY | Highmark Stadium | |
| Mon | 10/12/2026 | A | Los Angeles Rams | | | | | Inglewood, CA | SoFi Stadium | |
| Sun | 10/18/2026 | A | Las Vegas Raiders | | | | | Paradise, NV | Allegiant Stadium | |
| Sun | 11/1/2026 | H | Baltimore Ravens | | | | | Orchard Park, NY | Highmark Stadium | |
| Mon | 11/9/2026 | A | Minnesota Vikings | | | | | Minneapolis, MN | U.S. Bank Stadium | |
| Sun | 11/15/2026 | A | New York Jets | | | | | East Rutherford, NJ | MetLife Stadium | |
| Sun | 11/22/2026 | H | Miami Dolphins | | | | | Orchard Park, NY | Highmark Stadium | |
| Thu | 11/26/2026 | H | Kansas City Chiefs | | | | | Orchard Park, NY | Highmark Stadium | |
| Sun | 12/6/2026 | A | New England Patriots | | | | | Foxborough, MA | Gillette Stadium | |
| Sun | 12/13/2026 | A | Green Bay Packers | | | | | Green Bay, WI | Lambeau Field | |
| Sat | 12/19/2026 | H | Chicago Bears | | | | | Orchard Park, NY | Highmark Stadium | |
| Fri | 12/25/2026 | A | Denver Broncos | | | | | Denver, CO | Empower Field at Mile High Stadium | |
| Sun | 1/3/2027 | A | Miami Dolphins | | | | | Miami Gardens, FL | Hard Rock Stadium | |
| Sun | 1/10/2027 | H | New York Jets | | | | | Orchard Park, NY | Highmark Stadium | |
Exhibition game. Playoff game. A=Away game. H=Home game. N=Neutral site game. W=Win. L=Loss. T=Tie. OT=Overtime.