| SCORES |
|---|
| Day | Date | | Opponent | Result | Location | Venue | Attendance |
|---|
| Sun | 10/9/1921 | H | Cairo Independents | 7 | 0 | W | | Paducah, KY | League Park | |
| Sun | 10/16/1921 | H | Princeton Cardinals | 0 | 0 | T | | Paducah, KY | League Park | 1200 |
| Sun | 10/23/1921 | H | Anna | 0 | 7 | L | | Paducah, KY | League Park | |
| Sun | 10/30/1921 | A | Cairo Independents | 39 | 6 | W | | Cairo, IL | Bridgeview Park | |
| Sun | 11/6/1921 | H | Murphysboro (Illinois) | 28 | 0 | W | | Paducah, KY | League Park | |
| Fri | 11/11/1921 | A | Evansville Crimson Giants | | | - | | Evansville, IN | Bosse Field | |
| Fri | 11/11/1921 | H | Anna | 5 | 0 | W | | Paducah, KY | League Park | |
| Sun | 11/20/1921 | H | Princeton Cardinals | 7 | 6 | W | | Paducah, KY | League Park | |
| Sun | 12/4/1921 | A | Anna | 12 | 14 | L | | Anna, IL | | |
| Sun | 12/18/1921 | A | Evansville Crimson Giants | 0 | 0 | T | | Evansville, IN | Bosse Field | |
Exhibition game. Playoff game. A=Away game. H=Home game. N=Neutral site game. W=Win. L=Loss. T=Tie. OT=Overtime.
| Schedule Notes |
|---|
| 11/11/1921 | Evansville Crimson Giants | Canceled |
| 12/4/1921 | Anna | Postponed from 11/27 |
